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Big moments in Biology

Here is a snapshot of some of the major scientists who have contributed to the development of ideas in Biology.

Alexander Fleming

Alexander Fleming was a scientist who worked on a variety of things but he is better known for his famous 1928 experiments in which he was working on bacteria called Staphylococcus which causes sore throats and other illnesses. After leaving some petri dishes with a culture of staphylococcus for some days, he observed that some dishes had mould (fungi) growing in them in addition to bacteria. What was unusual was that the area near the mould had no bacteria around it. He hypothesised that the mould probably produced a chemical that killed the bacteria and carried out further experiments to verify this. Indeed this came up to be correct and the chemical was later called penicillin after the name of the fungus which produces it.
In his busy scientific life, Fleming published his findings but did not go ahead to isolate penicillin. Other scientists, Howard Florey and Ernst Chain carried out further experiments and isolated and purified penicillin. Penicillin is a very useful antibiotic which kills bacteria by stopping the formation of their cell walls during reproduction. It is used to treat bacterial diseases. Penicillin was very useful in treating wound infections during the 2nd World war. There was a race to produce it in large quantities. More antibiotics have been developed similarly since the discovery of penicillin.

Reflective thoughts:

a) What does this story teach us about scientific discoveries?

b) What does Fleming's story teach us about making scientific observations?

c) Imagine you were Fleming, what other hypotheses could you have come up with?

d) Test Fleming's hypothesis: Make a plan of how you could conduct an investigation to test Fleming's hypothesis. Identify all the 3 kinds of variables (dependent, independent, control).

e) Fleming's busy life- Yeeh, but not the end of the story! Florey and Chain's work- what does this teach us about scientific discoveries? Make a few points to brainstorm and discuss with a friend. Is it fair for others to claim credit rather than the original discoverer? Why, why not?

f) Penicillin has been produced and used in tonnes since World War 2,

i. What have been the problems with its excesssive and indisciminate use?

ii. Give and explain to someone a modern day problem/infection caused by this.

Edward Jenner

Another big moment which started from careful, critical observation is the story of Edward Jenner. In the 1780s, smallpox was a devastating disease worldwide. Englishman Jenner observed that people who milked cows caught a mild form of smallpox, called cow pox and never contacted smallpox. His hypothesis was that if you are injected with cowpox (mild), it would make the body able to fight off smallpox (deadly).

Dangerous experiment!
Jenner went on to extract cow pox germs/puss from milkmaid Sarah Nelmes’s sores and deliberately infected local farmer’s son James Phipps. Poor boy! James suffered from cowpox  and recovered after 6 weeks. Jenner then deliberately infected James with real deadly smallpox germs. Is this guy crazy? Interestingly, James did not catch smallpox: Hooray!-the world’s first vaccination! This procedure is still in use today and has helped save billions of people from infections.

Louis Pasteur

Anyone fancies studying rotting things?
Pasteur was interested in fermentation, a chemical reaction which happens when meat, fruits decay, milk sours, alcohol ferments. Concerned that brewers were losing a lot of beer in France due to beer turning sour, Pasteur looked at beer broth under a microscope. Expecting to find only round yeast cells, he also found small rod-shaped cells. This finding led him to conclude that there were ‘bad microbes’ in the broth which cause the beer to turn sour. Pasteur came up with a solution: gently heat the broth to 60 degrees Celsius and allow it to cool before packaging to kill the bad bacteria. This procedure called pasteurisation is still in use today especially with milk hence pasteurised milk!

Galvani and reanimation- some gory stuff from the Italian gang!

What makes us tick? I mean, think, feel, move etc?... The nervous system!

We could not answer these questions were it not for some gory stuff by Italian Luigi Galvani and his nephew Giovanni Aldini. During frog dissections, Galvani noticed that a frog leg twitched when touched by a scalpel that had been in an electric current. It was like electricity animated/brought to life the frog leg. Further experiments by his nephew Giovanni in London enabled us to understand the relationship between electricity and our nervous and muscular systems- messages are carried as electric current-aka impulse!

In 1818, Giovanni carried out an experiment using a convicted criminal’s body,  Matthew Clydesdale who had been hanged. Giovanni and his collaborators passed electrical current through 2 electrodes (metal plates), one embedded in Matthew’s ears and another in the rectum. Sad! The result was amazing! They observed contractions in the muscles of the face, and even opening of one of the eyes. Conclusion: Matthew reanimated! The point is: although grim, the experiment helped with our understanding of the nervous and muscular systems.